Vitamin K status in Children with Osteogenesis Imperfecta

Vitamin K status in Children with Osteogenesis Imperfecta - KinOI

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON48934

Enrollment

Registered

2018-03-21

Start date

2018-05-23

Completion date

Unknown

Last updated

2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Brittle bone disease

Interventions

None listed

Eligibility

Age

2 Years to 17 Years

Inclusion criteria

Inclusion criteria: Patients: - Genetically confirmed Osteogensis Imperfecta (O.I.) type I-IV - age 0-18 years - at least once a year bisphosphonate infusions as part of regular care, Controls: - no O.I. - age 0-18 years - needing orthopaedic or ear, nose, throat surgery so that they will already get an infusion line.

Exclusion criteria

Exclusion criteria: Patients: - Not genetically confirmed O.I. type I-IV - using vitamin K supplementation, Controls: - known disease affecting vitamin K or bone turnover - using vitamin K supplementation

Design outcomes

Primary

Measure	Time frame
- vitamin K levels in blood - osteocalcin levels in blood - bone turnover markers in blood (i.e. Ntx (N-terminal telopeptide) & BAP (Bone Alkaline Phosphatase))	—

Countries

Netherlands

Outcome results