Epilepsy and anxiety- targeting a vicious cycle: Comparison of cognitive behavioural therapy (CBT), eye movement desensitization and reprocessing (EMDR) therapy and wait-list in targeting epilepsy-related anxiety and posttraumatic stress

Epilepsy and anxiety- targeting a vicious cycle: Comparison of cognitive behavioural therapy (CBT), eye movement desensitization and reprocessing (EMDR) therapy and wait-list in targeting epilepsy-related anxiety and posttraumatic stress - CBT and EMDR in the treatment of epilepsy-related anxiety

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON48908

Enrollment

Registered

2018-10-05

Start date

2019-03-15

Completion date

Unknown

Last updated

2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

epilepsy

Interventions

CBT and EMDR therapy will be delivered using a maximum of 10 sessions of 90 minutes by experienced therapists. CBT and EMDR are both standardized trauma-focused treatments. CBT is intended to reduce

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: -Diagnosis of definite epilepsy -Epilepsy-related anxiety symptoms and/ or a diagnosis of (subtreshold) posttraumatic stress disorder (PTSD) -18 years or older

Exclusion criteria

Exclusion criteria: -The presence of psychological symptoms other than anxiety or PTSD in more urgent need of treatment (e.g. suicidal intent/acts or acute psychosis) -Not able to read/write and communicate in the Dutch language -Currently receiving another form of psychological treatment -Presence of psychogenic non-epileptic seizures -Estimated IQ

Design outcomes

Primary

Measure	Time frame
The primary outcome measures are: Anxiety: -Hospital Anxiety and Depression Scale- anxiety -Symptom Checklist-90-R- anxiety -Severity of PTSD symptoms (PTSD Checklist for Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition) -Self-reported anxiety (diary) Physiological stress: -Electrocardiography (ECG) heart rate variability (standard deviation of the NN (R-R) intervals, low and high frequency activity)	—

Measure

Time frame

The primary outcome measures are: Anxiety: -Hospital Anxiety and Depression Scale- anxiety -Symptom Checklist-90-R- anxiety -Severity of PTSD symptoms (PTSD Checklist for Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition) -Self-reported anxiety (diary) Physiological stress: -Electrocardiography (ECG) heart rate variability (standard deviation of the NN (R-R) intervals, low and high frequency activity)

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Secondary

Measure	Time frame
De secundary outcome measures are: • Self-reported number of seizures (diary) • Seizure severity (Liverpool Seizure Severity Scale 2.0) • Quality of life (Quality of Life in Epilepsy - 31) • Number of sessions needed to reduce the level of subjective distress related to the most stressful memory/scenario to zero Other study parameters/ possible confounders are: • Demographics (General questionnaire) • Treatment expectation (General questionnaire) • Disease characteristics (General questionnaire) • Personality (NEO Five-Factor Personality Inventory) • Depression (Hospital Anxiety and Depression Scale- depression) • Chronic everyday stress (Everyday Problem Checklist) • Psychopathology (Symptom Checklist-90-R)	—

Measure

Time frame

De secundary outcome measures are: • Self-reported number of seizures (diary) • Seizure severity (Liverpool Seizure Severity Scale 2.0) • Quality of life (Quality of Life in Epilepsy - 31) • Number of sessions needed to reduce the level of subjective distress related to the most stressful memory/scenario to zero Other study parameters/ possible confounders are: • Demographics (General questionnaire) • Treatment expectation (General questionnaire) • Disease characteristics (General questionnaire) • Personality (NEO Five-Factor Personality Inventory) • Depression (Hospital Anxiety and Depression Scale- depression) • Chronic everyday stress (Everyday Problem Checklist) • Psychopathology (Symptom Checklist-90-R)

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Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)