Bioavailability and metabolisme of curcumin
Conditions
Interventions
During 5 investigation fases, 5 different curcumin products will be taken
orally. Each product will be taken once.
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Healthy male, age * 18 years * Able to give written informed consent * Willing to follow the dietary regimens * Able to complete the entire study
Exclusion criteria
Exclusion criteria: * Major illness in the past 3 months * Gastrointestinal disease * History of cholecystectomy or other bile duct abnormalities * Metabolic or endocrine diseases * Drug abuse or alcoholism (>3 units of alcohol per day) * Use of prescription or non-prescription drugs and herbal or dietary supplements within 30 days prior to the first administration of curcumin supplement. With the exclusion of (non)prescription drugs used for their local effect and thus have no influence on the kinetics of curcumin. * Use of tobacco products * High usage of curcumin and black pepper in daily food/beverages * Known intolerance for curcumin or black pepper * Participation in another clinical trial in the 3 months prior to the start of the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Kinetic parameters of curcumin: AUC, clearance, volume of distribution, elimination half-life and possible Cmax and Tmax concentrations. | — |
Secondary
| Measure | Time frame |
|---|---|
| Kinetic parameters of curcumin and piperine of each of the 5 products. Influence of curcumin and piperine on different biochemical parameters. | — |
Countries
Netherlands
Outcome results
None listed