Periodontitis as a potential early risk indicator for diabetes mellitus, atherosclerotic cardiovascular disease, metabolic syndrome and obstructive sleep apnea syndrome

Periodontitis as a potential early risk indicator for diabetes mellitus, atherosclerotic cardiovascular disease, metabolic syndrome and obstructive sleep apnea syndrome - Periodontitis as signal for an underlying disease

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON48894

Enrollment

783

Registered

2018-02-22

Start date

2018-02-25

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

orale aandoeningen Cardiovascular disease Diabetes Metabolic Syndrome Obstructive Sleep Apnea Syndrome Periodontitis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Age * 40 years - (Patient) referred for periodontitis - (Control) visiting the dental school for regular dental check-up without periodontitis - Able and willing to give written informed consent and comply with the requirements of the study protocol.

Exclusion criteria

Exclusion criteria: None

Design outcomes

Primary

Measure	Time frame
To investigate, within a dental setting, the differences between periodontitis and non-periodontitis patients in: - The prevalence of preDM and DM - The 10-year-risk of ASCVD - The prevalence of MetS - The risk of OSAS (low, intermediate, high)	—

Secondary

Measure	Time frame
Secondary Objectives (cross-sectional): - To investigate the differences in (pre)DM prevalence, 10-year-risk of ASCVD, MetS prevalence and OSAS risk between non, mild/moderate and severe periodontitis patients - To measure qualitatively and quantitatively in a mouth rinse the same biochemical markers as in the venipuncture/finger stick procedure - To study the oral microbiome in a mouth rinse in relation to pre-DM, DM, 10-year-risk of ASCVD, MetS and OSAS between non, mild/moderate and severe periodontitis patients Secondary Objective(s) (longitudinal): - To evaluate whether patients visited their primary care physician based on the outcomes of the above mentioned screening for preDM, DM, 10-year-risk of ASCVD, MetS and OSAS - To explore the changes of biochemical markers over time in blood and oral rinse samples of periodontitis patients who underwent standard treatment of care in the clinics of ACTA - To study the oral microbiome in a mouth rinse in relation to pre-DM, DM, 10-year-risk of ASCVD and MetS in periodontitis patients who underwent standard treatment of care in the clinics of ACTA	—

Measure

Time frame

Secondary Objectives (cross-sectional): - To investigate the differences in (pre)DM prevalence, 10-year-risk of ASCVD, MetS prevalence and OSAS risk between non, mild/moderate and severe periodontitis patients - To measure qualitatively and quantitatively in a mouth rinse the same biochemical markers as in the venipuncture/finger stick procedure - To study the oral microbiome in a mouth rinse in relation to pre-DM, DM, 10-year-risk of ASCVD, MetS and OSAS between non, mild/moderate and severe periodontitis patients Secondary Objective(s) (longitudinal): - To evaluate whether patients visited their primary care physician based on the outcomes of the above mentioned screening for preDM, DM, 10-year-risk of ASCVD, MetS and OSAS - To explore the changes of biochemical markers over time in blood and oral rinse samples of periodontitis patients who underwent standard treatment of care in the clinics of ACTA - To study the oral microbiome in a mouth rinse in relation to pre-DM, DM, 10-year-risk of ASCVD and MetS in periodontitis patients who underwent standard treatment of care in the clinics of ACTA

—

Countries

Netherlands

Outcome results