The effects of protein ingestion and exercise on plasma and dialysate amino acid concentrations during hemodialysis

The effects of protein ingestion and exercise on plasma and dialysate amino acid concentrations during hemodialysis - Intradialytic protein ingestion and exercise study (IPES)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON48888

Enrollment

Registered

2018-08-14

Start date

2019-01-30

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Amino acid loss during hemodialysis hemodialysis

Interventions

During four HD sessions, patients will (A) ingest a placebo drink, (B) ingest a placebo drink and perform aerobic exercise, (C) ingest a protein supplement, and (D) ingest a protein supplement and p

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Aged >18 years - Ability to provide written informed consent - Hemodialysis treatment for >3 months - Well-functioning arteriovenous shunt in upper or lower arm

Exclusion criteria

Exclusion criteria: - Unstable cardiac status (i.e. cardiac ischemia) - Physical limitations affecting usage of the bike - Poor blood sugar control - Active infection or illness - Poorly functioning shunt - Previous episodes of intradialytic hypotension related to food intake - Hospitalization

Design outcomes

Primary

Measure	Time frame
Primary study parameters are amino acid loss into the dialysate and plasma total amino acid concentrations.	—

Secondary

Measure	Time frame
Secondary study parameters are the loss of essential amino acids into the dialysate, plasma essential amino acid, glucose, and insulin concentrations, interstitial glucose concentrations, and changes in blood pressure.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)