Detection of FIT- , fecal- and mucosa- associated microbiome and microRNA in patients with suspected colorectal adenomas or cancer

Detection of FIT- , fecal- and mucosa- associated microbiome and microRNA in patients with suspected colorectal adenomas or cancer - Microbiome and MicroRNA in patients with suspected CRC or adenomas.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON48887

Enrollment

160

Registered

2019-07-16

Start date

2017-10-17

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal cancer

Interventions

Colorectal cancer

Faecal immunochemical test (FIT)

Microbiome

MicroRNA

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: - Participants are between 50-75 years old. - Positive FIT in national CRC screening program - Suspicion of CRC - Willing to collect two FIT samples, one stool sample from one stool and fill out one questionnaire

Exclusion criteria

Exclusion criteria: - Unwilling or not able to give informed consent

Design outcomes

Primary

Measure	Time frame
The main study parameter will be the analysis of the microbiome and miRNA in relation to colorectal cancer and adenomas.	—

Secondary

Measure	Time frame
To assess the possibility of using the microbiome in a FIT as screening tool for CRC To assess the possibility of using miRNA panels in a FIT as screening tool for CRC To assess the difference in diversity and composition of the microbiome in FIT, stool sample and mucosal biopsy To assess the difference in diversity and composition of miRNA in FIT, stool sample and mucosal biopsy	—

Countries

The Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)