Obesity overweight
Conditions
Interventions
Oral sham feeding of and intragastric delivery of quinine (a bitter agent)
versus placebo.
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Based on medical history and previous examination, no gastrointestinal complaints can be defined. - Age from 18 until 65 years. This study will include healthy adult subjects (male and female). - BMI from 18 until 25 kg/m2 - Bodyweight stable over at least the last 6 months (up until 5% weight change allowed)
Exclusion criteria
Exclusion criteria: - History of severe cardiovascular, respiratory, urogenital, gastrointestinal/ hepatic, hematological/immunologic, HEENT (head, ears, eyes, nose, throat), dermatological/connective tissue, musculoskeletal, metabolic/nutritional, endocrine, neurological/psychiatric diseases, allergy, major surgery and/or laboratory assessments which might limit participation in or completion of the study protocol. The severity of the disease (major interference with the execution of the experiment or potential influence on the study outcomes) will be decided by the principal investigator. - Use of medication that can influence study end-points (to be discussed by medical doctor and principal investigator), including vitamin supplementation, within 14 days prior to testing - Administration of investigational drugs or participation in any scientific intervention study which may interfere with this study (to be decided by the principle investigator), in the 180 days prior to the study - Major abdominal surgery interfering with gastrointestinal function (uncomplicated appendectomy and hysterectomy allowed, and other surgery upon judgement of medical doctor and principle investigator) - Dieting (medically prescribed, vegetarian, diabetic, macrobiological, biological dynamic) - Unwillingness to eat lasagna bolognese meal - Pregnancy, lactation - Excessive alcohol consumption (>20 alcoholic consumptions per week) - Smoking - Non-tasters of bitter
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Food intake during an ad libitum pasta meal in the form of a pre made lasagna. | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS scores for satiety and GI symptoms. Heart rate variability (HRV) | — |
Countries
Netherlands
Outcome results
None listed