Improving transcranial direct current stimulation by targeting the motor network

Improving transcranial direct current stimulation by targeting the motor network - Motor network tDCS

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON48855

Enrollment

105

Registered

2018-03-27

Start date

2018-05-24

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cerebrovascular accident Stroke

Interventions

Participant 21 to 55: Subjects receive conventional, motor network or sham network tDCS over the motor cortex for 10 minutes at an intensity of no more than 2 mA per electrode and at most 4 mA in to

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Age between 18-35 years Healthy (no history of neurological disorders) Right-handedness

Exclusion criteria

Exclusion criteria: History of neurological or psychiatric disorders Implants or metal parts in the head Usage of medication or drugs that effect the nervous system Neuromodulatory stimulation in the last month Pregnancy

Design outcomes

Primary

Measure	Time frame
Participant 1 to 20: To explore what type of brain activity is related to motor learning and what activity is related to simple motor action. Participant 21 to 55: The main objective of the study is to reproduce the findings of Fischer et al. (2017), who demonstrated that stimulating the M1 motor network increases the cortical excitability, assessed with TMS. Participants will receive all three types of stimulation (conventional, motor network and sham network), separated by at least 48 hours, for 10 minutes. Transcranial magnetic stimulation (TMS) will be applied to assess cortical excitability at fixed time points after stimulation. The average cortical excitability will be compared between conditions at all time points. Participant 56 to 105: The main objective of the study is to investigate the influence of transcranial direct current stimulation (tDCS) on brain activity. Participants will receive all three types of stimulation (conventional, motor network and sham network). Participants will be asked to execute a motor learning task before, during and after brain stimulation. During the motor learning task, brain activity will be measured by using electroencephalography (EEG). Before and after the motor learning task, brain activity at rest will be measured. The three sessions will be separated by at least 48 hours. The influence of tDCS will be investigated by comparing brain activity before and after tDCS.	—

Measure

Time frame

Participant 1 to 20: To explore what type of brain activity is related to motor learning and what activity is related to simple motor action. Participant 21 to 55: The main objective of the study is to reproduce the findings of Fischer et al. (2017), who demonstrated that stimulating the M1 motor network increases the cortical excitability, assessed with TMS. Participants will receive all three types of stimulation (conventional, motor network and sham network), separated by at least 48 hours, for 10 minutes. Transcranial magnetic stimulation (TMS) will be applied to assess cortical excitability at fixed time points after stimulation. The average cortical excitability will be compared between conditions at all time points. Participant 56 to 105: The main objective of the study is to investigate the influence of transcranial direct current stimulation (tDCS) on brain activity. Participants will receive all three types of stimulation (conventional, motor network and sham network). Participants will be asked to execute a motor learning task before, during and after brain stimulation. During the motor learning task, brain activity will be measured by using electroencephalography (EEG). Before and after the motor learning task, brain activity at rest will be measured. The three sessions will be separated by at least 48 hours. The influence of tDCS will be investigated by comparing brain activity before and after tDCS.

—

Secondary

Measure	Time frame
Participant 21 to 55: To assess correlation between pre-TMS cortical activity (measured with EEG) and TMS amplitude (TMS/EMG). To assess the relation between tDCS-induced changes in TMS excitability and EEG signals. Participant 56 to 105: To investigate the influence of transcranial direct current stimulation (tDCS) on motor learning.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)