Wheeze in preschool children: the predictive value of episodic viral wheeze and multiple-trigger wheeze in the development of childhood asthma.

Wheeze in preschool children: the predictive value of episodic viral wheeze and multiple-trigger wheeze in the development of childhood asthma. - WHEEP follow-up study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON48853

Enrollment

171

Registered

2019-04-25

Start date

2019-08-07

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

wheeze

Interventions

None listed

Eligibility

Age

2 Years to 11 Years

Inclusion criteria

Inclusion criteria: The study population consists of 6- to 9-year-old children who were known for recurrent wheezing at the age of 1- to 4- years, treated by hospital-based paediatricians and included in the previous (WHEEP)study. Recurrent wheezing was defined as a minimum of 3 reported episodes in the year before inclusion, of which at least one must have been confirmed by a pediatrician. Children were then recruited from pediatric departments of ten general and academic hospitals in the Netherlands. During the 1-year (WHEEP)study period wheeze patterns were classified from patient diaries and compared to pediatrician assigned phenotypes.

Exclusion criteria

Exclusion criteria: No new exclusion criteria. All children who participated in the former study are eligible. As in the former study children of whom their parents do not understand the Dutch language are not eligible.

Design outcomes

Primary

Measure	Time frame
The primary outcome measure is the predictive value of the preschool wheezing phenotype (diary based as wel as clinically based) in the development of childhood asthma.	—

Secondary

Measure	Time frame
The sensitivity and specificity of the following asthma predictive scores in our cohort will be evaluated: the Asthma Predictive Index (API) and the Prevention and Incidence of Asthma and Mite Allergy risk score (PIAMA). Another secondary outcome measure is the predictive value of viral upper respiratory tract infections at preschool age in the development of asthma. The results of nasal swabs, collected in the previous study, will be compared to asthma status at the age of 6 to 8 years. Moreover, we will study differences in microbiome at preschool age between children who develop childhood asthma and children who do not. In order to compare the microbiome at preschool age to the microbiome at the age of 6 to 8 years, throat swabs will be collected.	—

Measure

Time frame

The sensitivity and specificity of the following asthma predictive scores in our cohort will be evaluated: the Asthma Predictive Index (API) and the Prevention and Incidence of Asthma and Mite Allergy risk score (PIAMA). Another secondary outcome measure is the predictive value of viral upper respiratory tract infections at preschool age in the development of asthma. The results of nasal swabs, collected in the previous study, will be compared to asthma status at the age of 6 to 8 years. Moreover, we will study differences in microbiome at preschool age between children who develop childhood asthma and children who do not. In order to compare the microbiome at preschool age to the microbiome at the age of 6 to 8 years, throat swabs will be collected.

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Countries

Netherlands

Outcome results