Non-invasive detection of potential epileptogenic cortical brain lesions

Non-invasive detection of potential epileptogenic cortical brain lesions - TMS insult induction / TMS II

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON48843

Enrollment

Registered

2019-02-21

Start date

2019-03-05

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

convulsions epilepsy

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Admitted to the epilepsy monitoring unit for presurgical evaluation - Suspect superficial MRI region(s) reachable with TMS stimulation (depth

Exclusion criteria

Exclusion criteria: - Pregnancy - Mentally incapacitated - Major radiological evidence of asymmetry between hemispheres - Individuals with a cochlear implant, Pacemaker, deep brain stimulator or other implanted electronic devices - Metal and/or metal fragments in head

Design outcomes

Primary

Measure	Time frame
Positive predictive value of the TMS evoked seizures for successfully localizing the epileptogenic zone.	—

Secondary

Measure	Time frame
Congruency of the TMS evoked epileptiform abnormalities with the epileptogenic zone as determined in positive surgical outcome cases: - Epileptiform afterdischarges - TMS-EEG excitability parameters Other parameters: - Type, depth and extension of lesion - Pathological assessment of lesion - Type of epilepsy, clinical semiology of seizures - Result of the pre-surgical evaluation - Post-surgical outcome	—

Measure

Time frame

Congruency of the TMS evoked epileptiform abnormalities with the epileptogenic zone as determined in positive surgical outcome cases: - Epileptiform afterdischarges - TMS-EEG excitability parameters Other parameters: - Type, depth and extension of lesion - Pathological assessment of lesion - Type of epilepsy, clinical semiology of seizures - Result of the pre-surgical evaluation - Post-surgical outcome

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Countries

Netherlands

Outcome results