Geriatric anti-donor T-cell activity and development of alloreactive long-term hypo-responsive T cell function (GANDALF); Post-transplant development of anti-donor-specific hypo-responsiveness; Lessons to be learned from older kidney transplant recipients

Geriatric anti-donor T-cell activity and development of alloreactive long-term hypo-responsive T cell function (GANDALF); Post-transplant development of anti-donor-specific hypo-responsiveness; Lessons to be learned from older kidney transplant recipients - GANDALF

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON48839

Enrollment

540

Registered

2018-03-27

Start date

2018-06-25

Completion date

Unknown

Last updated

2026-08-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

orgaantransplantatie anti-donor immunity post-transplant anti-donor reactivity

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: -18 years or older; i.e. between 18-45 years and >54 years -kidney transplant recipient who is supervised at the Erasmus University Medical Center in Rotterdam -recipient of a living or post mortal donor kidney -stable graft function (defined as absence of recurrence disease and chronic rejection) 3-5 or 5-10, 10-15, 15-20 and >20 years after transplantation (cross-sectional sub-study)

Exclusion criteria

Exclusion criteria: age

Design outcomes

Primary

Measure	Time frame
The primary study parameter comprises of a detailed characterization of anti-donor reactivity at different time-points following kidney transplantation to identify the mechanism(s) of DSH.	—

Countries

Netherlands

Outcome results