first episode psychosis schizophrenia
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: For patients: - First episode psychosis - Age 18-35 years old;For healthy contols: - Age 18-35 years old
Exclusion criteria
Exclusion criteria: - Antipsychotic use longer than one year - Dependence on other substances of abuse than nicotine or cannabis - Use of amphetamine, cocaine or medication for ADHD (attention deficit hyperactivity disorder), since these drugs influence the dopamine system - Neurological disorder (e.g. epilepsy) or evidence of brain damage - Inability to provide informed consent;In addition to the exclusion criteria mentioned above, healthy control subjects are not allowed to have any kind of psychiatric disorder;Exclusion criteria directly related to MRI scanning: - Contra-indications for MRI (including pacemaker, ferromagnetic implants, claustrophobia) - Pregnancy;Exclusion criteria directly related to PET/CT scanning (for subgroup of 40 patients): - Participation in a scientific examination where radiation was used, in the last year. - Positive urine drug screen on the day of the PET/CT scan. Participants will be tested on cannabis, amphetamine, XTC, cocaine and opiates. Only recent cannabis use will be accepted. - In women: positive pregnancy test on the day of the PET/CT scan and lactation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Treatment resistance - Neuromelanin contrast ratio on nMRI - Glutamate/Creatine ratio on MRS in ACC - Plasma DDC activity - [18F]DOPA influx (Ki) value (for subgroup of 40 patients) | — |
Secondary
| Measure | Time frame |
|---|---|
| - Side effects of antipsychotics - Symptom scores on PANSS - Neuropsychological ratings | — |
Countries
Netherlands
Outcome results
None listed