Age and performance: the relation between brain structure and cognition - Part II

Age and performance: the relation between brain structure and cognition - Part II - Age and performance * Part II

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON48809

Enrollment

Registered

2019-05-21

Start date

2019-06-26

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

geen aandoening n.v.t.

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Having participated in the study *Age and performance: the relation between brain structure and cognition*. - Right-handed - Normal (or corrected to normal) vision

Exclusion criteria

Exclusion criteria: - Not matching the inclusion criteria - MR incompatible (possibility of any incompatible metal objects inside the body)

Design outcomes

Primary

Measure	Time frame
Cognitive measures: Number of words remembered (15 word test), variable representing the Simon effect for inhibition (Simon task), completion time (TMT). Imaging measures as derived from MRI scans: Whole brain grey matter volume, cortical thickness in the superior frontal gyrus, FA of the prefrontal cortex	—

Secondary

Measure	Time frame
Main study parameters of cognitive performance consist of the default outcome measures of each cognitive task. Regarding the MRI scans we derive volumetric data of grey matter, white matter and cerebral spinal fluid,(mean) cortical thickness, percentage of white matter hyperintensities in relation to brain volume, and DTI scalar values (FA, MD, AD and RD). Standardized change scores of these measures will be calculated.Further more information on reduction of working hours and possible retirement will be taken into consideration.	—

Measure

Time frame

Main study parameters of cognitive performance consist of the default outcome measures of each cognitive task. Regarding the MRI scans we derive volumetric data of grey matter, white matter and cerebral spinal fluid,(mean) cortical thickness, percentage of white matter hyperintensities in relation to brain volume, and DTI scalar values (FA, MD, AD and RD). Standardized change scores of these measures will be calculated.Further more information on reduction of working hours and possible retirement will be taken into consideration.

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Countries

Netherlands

Outcome results