Surgical trauma and postoperative immune suppression in breast-conserving surgery versus mastectomy: a pilot study

Surgical trauma and postoperative immune suppression in breast-conserving surgery versus mastectomy: a pilot study - BREAST

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON48770

Enrollment

Registered

2019-12-19

Start date

2020-06-15

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Breast surgery mamma surgery

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Female - Age * 18 years - Undergoing breast conserving surgery or mastectomy - Obtained informed consent

Exclusion criteria

Exclusion criteria: -

Design outcomes

Primary

Measure	Time frame
o Plasma concentration of DAMPs (nDNA, mtDNA, HMGB-1 and HSP70) and cytokines (TNF*, IL6 and IL10) o Ex vivo leucocyte responsiveness: IL-6 and IL-10 production upon LPS stimulation o HLA-DR mRNA expression as a measure of immune suppression o Serum soluble PD-L1	—

Countries

Netherlands

Outcome results