Epilepsy Seizures
Conditions
Interventions
None listed
Sponsors
Medisch Universitair Ziekenhuis Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: All subjects must be mentally competent (wilsbekwaam) and able to understand the patient information form and decide for participation. All subjects must be aged over 18 years old. All subjects must meet all inclusion requirements of the standard Scannexus screening form All subject must be included for DBS surgery at the MUMC+ for treatment of drug-resistant epilepsy
Exclusion criteria
Exclusion criteria: Neurological diseases other than epilepsy, such as brain tumours, stroke, severe neurotrauma*s, and neurodegenerative diseases. Foreign ferromagnetic objects in the subject*s body or other contra indications for MRI. Prior to scanning, subjects will fill out a screening form. This form will be sent with the information letter to all subjects (Appendices 4 and 5). The screening form will be filled out again on the day of the scan, to ensure any contra indications are known to both the subject and the scanning technician.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main radiological endpoint will be the location of the DBS electrode within the thalamic subnuclei and its structural and functional connectivity. De study parameters used are the DBS electrode contact coordinates (in y, x and z directions) and Euclidean distance of the implanted DBS electrode to the thalamic subnuclei defined by segmentation and by structural and functional MRI. The main clinical endpoint will be the reduction in seizure frequency after DBS. | — |
Countries
Netherlands
Outcome results
None listed