Improved prediction of recurrent stroke and detection of small volume stroke

Improved prediction of recurrent stroke and detection of small volume stroke - ENCLOSE

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON48750

Enrollment

720

Registered

2017-10-24

Start date

2018-01-23

Completion date

Unknown

Last updated

2026-07-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ischemic stroke

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria:  • Age >=18 years;  • Time from symptom onset until imaging is <9 hours*;  • Clinical diagnosis of acute ischemic stroke or TIA;  • Informed consent from patient or family after the admission scan (unless the patient died).  * Patients who awaken with stroke symptoms can only be included if they went to sleep without any stroke symptoms and the time from going to sleep until imaging is less than 9 hours.;To be eligible for a follow-up MRI, a subject must meet all of the following criteria:  • Occlusion distal to the A2 segment of the anterior cerebral artery, occlusion distal to the M1-M2 bifurcation of the middle cerebral artery, occlusion of the posterior cerebral artery (no occlusion of the basilar artery) or no visible occlusion as determined on the admission CTA scan;  • No contraindications for MRI.

Exclusion criteria

Exclusion criteria: • Patients with another diagnosis such as intracerebral hemorrhage, subarachnoid hemorrhage or tumor;  • Patients with known contrast allergy or renal failure.

Design outcomes

Primary

Measure	Time frame
• Stroke recurrence rate at 2 years; • Presence and volume of acute ischemic lesions on follow-up diffusion weighted imaging (DWI) MRI.	—

Secondary

Measure	Time frame
• Stroke recurrence rate at 2 days, 10 days and 90 days; • Cardiac thrombus on trans-thoracic echography (TTE), trans-esophageal echography (TEE) or ECG-gated cardiac CTA in patients with suspected thrombus on admission CTA (as part of standard clinical practice, patients with suspected cardiac thrombus on admission CTA and patients without an obvious other cause of ischemic stroke will be referred to a cardiologist to confirm or detect a cardioembolic source with trans-thoracic echography followed by trans-esophageal echography if necessary or additional ECG-gated cardiac CTA); • Atherosclerotic plaque composition of the extracranial internal carotid artery or carotid bifurcation on contrast enhanced MRI; • 90 day modified Rankin scale.	—

Measure

Time frame

• Stroke recurrence rate at 2 days, 10 days and 90 days; • Cardiac thrombus on trans-thoracic echography (TTE), trans-esophageal echography (TEE) or ECG-gated cardiac CTA in patients with suspected thrombus on admission CTA (as part of standard clinical practice, patients with suspected cardiac thrombus on admission CTA and patients without an obvious other cause of ischemic stroke will be referred to a cardiologist to confirm or detect a cardioembolic source with trans-thoracic echography followed by trans-esophageal echography if necessary or additional ECG-gated cardiac CTA); • Atherosclerotic plaque composition of the extracranial internal carotid artery or carotid bifurcation on contrast enhanced MRI; • 90 day modified Rankin scale.

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Countries

Netherlands

Outcome results