The smell of a sick liver in primary sclerosing cholangitis

The smell of a sick liver in primary sclerosing cholangitis - VOCs in PSC

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON48740

Enrollment

265

Registered

2018-11-20

Start date

2019-11-19

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

PSC Ulcerative colitis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Cases: Ulcerative colitis with or without PSC Controls (UC): Ulcerative colitis Controls (healthy): Able to give informed consent.

Exclusion criteria

Exclusion criteria: * Any disease compromising immune system (such as HIV positive status or patients after organ transplantations). * Any other liver disease * Active and untreated tuberculosis * Use of chemotherapy agents

Design outcomes

Primary

Measure	Time frame
VOCs pattern measured using Solid Phase Microextraction (SPME) in combination with Gas Chromatography coupled with time-of-flight-Mass Spectrometry (GC-tof-MS).	—

Secondary

Measure	Time frame
Various metabolites and biomarkers in the blood and fecal samples. As well as a one leaflet questionnaire containing questions about BMI, age, smoking & diet behavior and the Amsterdam Cholestatic Complaints Score and/or the Simple Clinical Colitis Activity Index.	—

Countries

Netherlands

Outcome results