Duchenne muscular dystrophy
Conditions
Interventions
the participant will be asked to perform an exercise task using an
MR-compatible ergometer mimicking stair walking.
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Objective 1 and 2: - Between 18-65 years old;Objective 3: - Between 18-35 years old
Exclusion criteria
Exclusion criteria: - Mentally disabled persons - Diagnosed with a musculoskeletal or neurological disorder - Pregnancy and a chance of being pregnant (as reported by the volunteer) - Not having a general practitioner - MRI contraindication (see appendix III): e.g. cardiac pacemaker, implants not approved for MRI (see www.mrsafety.com), claustrophobia, metal objects attached to the body that cannot be removed (fillings and most of other dental works are allowed). Decision on the MRI contraindication is made according to the guidelines outlined in the MR safety document of the Department of Radiology (http://iprova.lumc.nl/iDocument/Viewers/Frameworks/ViewDocument.aspx?DocumentID=2a2abd19-03e0-49d8-8681-916c2bc154e7&NavigationHistoryID=8178328&PortalID=181&Query=MR+safety)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Muscle characteristics, in terms of MRI and/or EMG outcome measures, of the lower extremity which correlate with the order in which muscles degenerate in DMD and BMD . | — |
Secondary
| Measure | Time frame |
|---|---|
| - | — |
Countries
Netherlands
Outcome results
None listed