Mayer Rokitanski Kuster Hauser syndrome
Conditions
Interventions
None listed
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: MRKH group (43 patients) - Diagnosed with MRKH syndrome - Age * 18 years - signed informed consent ;PCOS group:(43 patients) - Diagnosed with PCOS - Age * 18 years - signed informed consent ;endometriosis group: (43 patients) - Diagnosed with moderate-severe endometriosis - Age * 18 years - signed informed consent ;Control group: (43 patients) - Age * 18 years - Regular, ovulatory cycle - ICSI treatment for male infertility - signed informed consent
Exclusion criteria
Exclusion criteria: MRKH women - not willing to participate in the study PCOS group: - vaginal delivery in the medical history - diagnosed with endometriosis - not willing or able to sign the informed consent;Endometriosis group: - vaginal delivery in the medical history - diagnosed with PCOS - not willing or able to sign the informed consent;Control group: - diagnosed with PCOS/endometriosis - ICSI treatment after a total fertilization failure in IVF cycle - vaginal delivery in the medical history - not willing or able to sign the informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary study outcome is the AGDac in all 4 groups. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study outcomes are: - the difference in AGDaf and 2D:4D ratio in the four different patient groups (MRKH vs. PCOS vs. endometriosis vs. controls) The following parameters will also be monitored: age, ethnicity, BMI, medical history, signs of clinical hyperandrogenism (by questionnaire) and ovarian morphology by ultrasound. | — |
Countries
Netherlands
Outcome results
None listed