The Effects of Transfusion of Red blood cells In the critically ill II

The Effects of Transfusion of Red blood cells In the critically ill II - TETRIS2

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON48722

Enrollment

Registered

2017-07-21

Start date

2017-08-24

Completion date

Unknown

Last updated

2024-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anemia blood deficiency

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients who will receive an erythrocyte transfusion in the ICU (to correct for anemia) and are not suspected of an active bleeding.

Exclusion criteria

Exclusion criteria: * Patients who have not given informed consent * Patients who pose difficulties in securing blood products (e.g. rare blood groups) * Patients who receive more than 1 unit of RBCs in 1 transfusion episode * No arterial catheter in situ

Design outcomes

Primary

Measure	Time frame
Change in the expression of PS on erythrocytes before and after RBC transfusion and the influence of an inflammatory state in the receiver.	—

Secondary

Measure	Time frame
* Clearance rate of erythrocytes - expression of clearance markers, other than PS * markers of immune cell and endothelial cell activation and adhesion * complete blood count * Levels of fibrinogen, APTT, PTT and D-dimers in blood (to calculate DIC score) * markers of inflammatory host respons * Sublingual microcirculatory density and perfusion velocity, as visualized with SDF * Tissue oxygenation, as measured with NIRS * VO2 (oxygen uptake), DO2 (oxygen delivery), O2ER (oxygen extraction ratio) * Time on mechanical ventilation * Duration of ICU stay * Duration of hospital stay * 28 day mortality * DNA staining on residual red blood cell material, * Red blood cell deformability, activation status and cell-binding ability	—

Measure

Time frame

* Clearance rate of erythrocytes - expression of clearance markers, other than PS * markers of immune cell and endothelial cell activation and adhesion * complete blood count * Levels of fibrinogen, APTT, PTT and D-dimers in blood (to calculate DIC score) * markers of inflammatory host respons * Sublingual microcirculatory density and perfusion velocity, as visualized with SDF * Tissue oxygenation, as measured with NIRS * VO2 (oxygen uptake), DO2 (oxygen delivery), O2ER (oxygen extraction ratio) * Time on mechanical ventilation * Duration of ICU stay * Duration of hospital stay * 28 day mortality * DNA staining on residual red blood cell material, * Red blood cell deformability, activation status and cell-binding ability

—

Countries

Netherlands

Outcome results