Brain tumor
Conditions
Interventions
None listed
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients are 18 years or older at first diagnosis Patients are willing and able to give written informed consent Diagnosis of glioma is confirmed by histological examination Patients underwent surgery at least twice with minimal 6 months in between Patients are willing to contribute tumor tissue of both operations to the study Presence of normal non-neoplastic DNA or is available at time of inclusion If no normal DNA is available, patients are willing to donate 20 ml of blood to isolate normal DNA
Exclusion criteria
Exclusion criteria: Patients who do not meet the inclusion criteria will be excluded of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The present study aims to generate detailed molecular characterization of paired tumor samples (i.e. obtained at first operation and at the time of tumor recurrence) of patients with glioma, with specific interest for at least 100 well-annotated patients with IDH-mutant (1p/19q non-codeleted) astrocytomas. Molecular data will be correlated to clinical and imaging data of these patients to identify molecular and/or imaging markers indicative for early malignant progression. | — |
Secondary
| Measure | Time frame |
|---|---|
| To identify molecular alterations in the recurrent tumors that occur under pressure of different therapeutic modalities. To identify new targets for further therapeutic interference. | — |
Countries
Netherlands
Outcome results
None listed