cognitive impairment dementia MCI nervous system
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Diagnosis of aMCI based on neurologists evaluation. Age >=50 years aMCI will be defined as having a verbal memory score 1.5 standard deviations below the normative control values on both sub-scales. Signed written informed consent.
Exclusion criteria
Exclusion criteria: 1. History of psychiatric or neurological illness other than MCI 2. Metal implants (e.g., pacemaker, heart valves, vascular clips, eye-implants, copper containing intra-uterine devices, non-removable piercing, cerebral implants) 3. Any risk of having metal particles in the eyes 4. Tattoos containing iron oxide (often found in red pigments) 5. Claustrophobia 6. Alcohol or drug abuse 7. Excessive intake alcohol (>2 units per day); 8. Recent use of alcohol (2 days before the EEG and/or fMRI measurement). 9. Refusal to be informed of structural brain abnormalities that could be detected using MRI during the experiment 10. Severe scalp skin lesions 11. Color blindness
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| After two-weeks stimulation: - Change in fronto-temporal synchronization (measured by resting state EEG). - Change in working memory measured with the off-line n-back task and WAIS-WM. - Decreased reaction time (VRRT). | — |
Secondary
| Measure | Time frame |
|---|---|
| - Improvement in daily activities (IADL), functional connectivity (fMRI) during task and rest, general executive functioning and memory performance after two weeks of stimulation. - Duration of effects (up to one year). - Correlation of salivary levels of lactoferrin with change in EEG synchronization and cognitive performance | — |
Countries
Netherlands
Outcome results
None listed