Cardiac Surgery open hart operation
Conditions
Interventions
New guideline for peri- and postoperative antibiotic prophylaxes: withholding
dose at start CPB, postoperative dose at 8 and 16 hours from 1 gram cefazoline
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Informed consent Age >18 year Cardiac surgery with the use of CPB Use of cefazolin as antibiotic prophylaxis BMI
Exclusion criteria
Exclusion criteria: No informed consent Age 40 Active infection treated with antibiotics before surgery Kidney function impairment, defined as eGFR 3 times normal values.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time and concentration of cefazolin above the MIC of 2 mg/L. | — |
Secondary
| Measure | Time frame |
|---|---|
| * PK parameters on cefazolin in patients undergoing cardiac surgery Incidence of DSWI and concomitant use of antibiotics will be recorded in the database. We will not include incidence of DSWI as an secondary objective, since this is a rare complication and the study design in not suited to investigate this. Data on kidney and liver impairment (as defined in exclusion criteria) post-operatively will also be recorded in the database. | — |
Countries
Netherlands
Outcome results
None listed