Modelling of saliva gentamicin concentrations in neonates receiving gentamicin treatment

Modelling of saliva gentamicin concentrations in neonates receiving gentamicin treatment - Saliva gentamicin concentration in neonates

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON48679

Enrollment

Registered

2018-08-27

Start date

2018-10-08

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

antibiotic treatment

Interventions

None listed

Eligibility

Age

2 Years to 11 Years

Inclusion criteria

Inclusion criteria: Gentamicin treatment Admission to the neonatology ward , pediatrics/pediatric surgery department, obstetrics department or maternity ward of the AMC/Juliana children*s hospital (Haga Hospital) Signed informed consent from both parents prior to any study-mandated procedure

Exclusion criteria

Exclusion criteria: Congenital disease of the salivary glands Parent refusal Inability to sample saliva

Design outcomes

Primary

Measure	Time frame
Primary study paramters are the saliva gentamicin concentrations at different time-points.	—

Secondary

Measure	Time frame
Secundary study parameters of this study are gentamicin concentrations in plasma, correlation between plasma and saliva gentamicin, citric acid stimulation during saliva sampling (Y/N), sampling duration, salivary pH and sample volume.	—

Countries

Netherlands

Outcome results