Neural correlates of suicidal behaviour: a longitudinal study

Neural correlates of suicidal behaviour: a longitudinal study - Neural correlates of suicide

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON48668

Enrollment

Registered

2017-06-20

Start date

2017-10-19

Completion date

Unknown

Last updated

2025-12-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

self-harm suicide suicide attempt

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: All participants (N=94) - 18 - 60 years of age - Written informed consent Suicide attempt patients (N=46) - Had a recent suicide attempt as judged by a psychiatrist (not more than six months ago at moment of signing the informed consent) Patient and Healthy controls (N=48) - Matched to suicide attempt patients on age, sex, education, and handedness - Never attempted suicide Patient controls (N=24) - Matched to suicide attempt patients on psychopathology Healhty Controles (N=24) - No current suicidal ideation defined by a BSS=0

Exclusion criteria

Exclusion criteria: All participants: - Presence of a neurological disorder - A suicide attempt in light of auto-euthanasia in presence of a terminal somatic illness or primarily caused by a psychotic delusion or hallucination - Visual or hearing problems that cannot be corrected - Insufficient knowledge of the Dutch language - Not able to undergo 3 Tesla MRI scanning, these criteria include: (suspected) pregnancy, claustrophobia, MR incompatible implants or objects in the body (such as ear prostheses or other metal implants, operating clips or metal particles in the eye), tattoos containing pigments that form a safety risk, the refusal to be informed (by notifying the participants physician) of structural abnormalities that could be detected during the experiment. , For Healthy controls - A past or current psychiatric disorder

Design outcomes

Primary

Measure	Time frame
The main study parameter is brain activation/connectivity measured with functional magnetic resonance imaging (fMRI) during different types of emotional processing tasks and resting state. For the second objective, the main study endpoint will be the association between brain activation at first measurement and suicidal ideation/attempts at follow-up. For the third objective, the main endpoint will be change in brain activation at follow-up (second MRI scan) as compared to the first measurement.	—

Measure

Time frame

The main study parameter is brain activation/connectivity measured with functional magnetic resonance imaging (fMRI) during different types of emotional processing tasks and resting state. For the second objective, the main study endpoint will be the association between brain activation at first measurement and suicidal ideation/attempts at follow-up. For the third objective, the main endpoint will be change in brain activation at follow-up (second MRI scan) as compared to the first measurement.

—

Secondary

Measure	Time frame
n.a.	—

Countries

Netherlands

Outcome results