endocriene aandoeningen, obesitas Obesity
Conditions
Interventions
All participants will receive in random order (after the baseline mri) a
single-dose of calcitriol 4µg (= intervention) and 0.9% NaCl (= placebo). These
interventions will be scheduled approximately
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Age between 18 - 35 years - Ability to provide informed consent - Right-handedness - Stable weight (74 pmol/l at screening
Exclusion criteria
Exclusion criteria: - Any medical or psychiatrical disorder (except stable obesity-related glucose intolerance, hypertension, dyslipidemia and/or controlled hypothyroidism) - Subjects taking any of the following medications: anticonvulsants, corticosteroids, digitalis, magnesium-containing preparations (e.g. antacids), thiazide-diuretics, phosphodiesterase inhibitors, serotonergic medications (e.g. SSRI, SNRI, MAO inhibitors, buproprion, tricyclic antidepressants, St. John*s Wort), codeine (CYP2D6 inhibition), tamoxifen, timolol, warfarin, exogenous insulin, GLP-1 agonists, DPP4 inhibitors, SGLT2 inhibitors, beta-blockers, homeopathic supplements - The use of weight loss agents (e.g. orlistat, phentermine, topiramate, fenfluramin, dexfenfluramine, amphetamines, GLP-1 agonists) or use within 3 months prior to study - Weight loss surgery or gastrectomy - Childhood-onset obesity - Breakfast skippers - Shift workers - Contraindication to MRI scanning (e.g. claustrophobia, pacemaker, metal IUD) - Significant sensory or motor impairment - Subjects who cannot adhere to the experimental protocol for any reason
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The effect of calcitriol on brain activity in the hypothalamus and reward areas as well as functional connectivity as measured by fMRI during food stimuli. | — |
Secondary
| Measure | Time frame |
|---|---|
| The effect of calcitriol on: - Subjective (VAS) scores of hunger and satiety - Neuropsychological functioning and feeding behavior characteristics as assessed by questionnaires - Objective scores of hunger and satiety as measured during an ad-libitum buffet meal - The gut microbiota and its association with changes in fMRI responses - Circulating levels of glucose, insulin, and hormones | — |
Countries
Netherlands
Outcome results
None listed