The pathophysiology of post-extubation dysphagia in ICU patients

The pathophysiology of post-extubation dysphagia in ICU patients - Post-extubation dysphagia

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON48639

Enrollment

Registered

2017-12-07

Start date

2019-01-22

Completion date

Unknown

Last updated

2026-07-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

slikstoornissen Dysphagia swallowing disorders

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: • Age >= 18 years • Informed consent • Extubated after endotracheal intubation for more than 5 days (> 5 days) • Between RASS -2 and +2 • Able to sit right up • No respiratory insufficiency/failure (for this study defined as a SpO2 < 92%  with a minimum of 3 L nasal oxygen). Inclusion criteria of the group of healthy persons:  • Age >= 18 years • Informed consent

Exclusion criteria

Exclusion criteria: • Pre-existing dysphagia • Tracheostomy or previous tracheostomy • History of prior intubation < 3 months ago • Head/neck surgery, head/neck radiation or head/neck disease • Pre-existent esophageal disorder • Coagulopathy (thrombocytes < 50*10^9 /l, or PT/APTT > 1.5 times the reference  value, or fibrinogen < 1000 mg/l, or use of therapeutic anticoagulation drugs) • Allergy for xylometazoline (only if indicated) • Allergy for methylene blue • Known pregnancy • Known G6PD deficiency

Design outcomes

Primary

Measure	Time frame
The main study parameter is the underlying pathophysiology of PED, which will be described qualitatively. Goal is to classify patients into pathophysiological categories.	—

Secondary

Measure	Time frame
The secondary outcome parameters are the feasibility of the combination of techniques and possible interactions.	—

Countries

Netherlands

Outcome results