postprandial anabolic response
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Ability to provide informed consent - 18-30 years or older than 65 years at the time of signing the informed consent - Body mass index (BMI) 18.5- 25 kg/m2 - Caucasian men - General good health as determined by medical history, physical examination and blood chemistry by a physician. - HOMA-IR index: * 2.0 (measured as fasting insulin (pmol/L) x fasting glucose (mmol/L) / 135)
Exclusion criteria
Exclusion criteria: - Major illness in the past 3 months - Use of any medication - Gastro-intestinal disease that may influence bile acid signalling metabolism - History of cholecystectomy or other bile duct abnormalities - Tobacco smoking - Drugs abuse - Alcoholism (>3 units a day) - Blood chemistry (fasted): * Creatinine >120 µM * Glucose * 5.6 mmol/L * >2 times upper limit reference interval of the following: ASAT, ALAT, GGT, AP - Strenuous exercise for at least 3 days prior to each study day, defined as more than 1 hour of exercise per day. - Hypersensitivity to substances in Nutridrink
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters are postprandial bile metabolism expressed as concentration, area under the curve and inflammatory response as determined by the whole blood leukocyte counts and plasma cytokines. | — |
Secondary
| Measure | Time frame |
|---|---|
| . To assess the effect of a MMT on: * Glucoregulatory and gut hormones * Lipid profiles * Resting energy expenditure * Appetite and satiety * Body composition * Micriobiome | — |
Countries
Netherlands
Outcome results
None listed