rectal cancer
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Informed consent for PLCRC; * Informed consent for the use of clinical data * Informed consent for future studies within PLCRC; * Eligible for neoadjuvant radiotherapy; * Eligible for rectal surgery by Total Mesorectal Excision (either Low Anterior Resection, Abdominoperineal Resection or Hartmann resection).
Exclusion criteria
Exclusion criteria: * Patients with distant metastasis requiring surgery between chemoradiation and rectal surgery; * MRI contraindications according to the MR safety protocol of the imaging division of the UMC Utrecht.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The accuracy of 7 Tesla MRI in determining the residual tumour volume, location, and extension after neoadjuvant radiotherapy. Location is determined by comparison of the center of the tumour on 7T images and in whole mount pathology. The tumour extension is defined as the distance between the outline of the tumour in pathology and the tumour outline on imaging. | — |
Secondary
| Measure | Time frame |
|---|---|
| Define the most optimal 7T sequences in determining tumour volume, validated with pathology;. If available, a comparison of tumour volume as determined on 7T and 3T images will be made. | — |
Countries
Netherlands
Outcome results
None listed