IBS Irritable Bowel Syndrome
Conditions
Interventions
IBS patients will be treated with FMT to assess the difference in engraftment
in patients pre-treated with bowel lavage (conventional arm) compared to
patients not pre-treated with bowel lavage (exp
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a subject must meet the following criteria: 1. Post-infectious or post antibiotic use IBS, IBS defined by the ROME IV criteria 2. 18 years or older 3. Provide informed consent
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: 1. Swallowing disorders, 2. Pregnancy, 3. Antibiotics use during study or shortly prior to start of study 4. Need for chemotherapy 5. ICU-admission 6. IBD / Celiac Disease 7. Severe immunecompromisation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main study endpoint: the level of engraftment of donor microbiota in experimental and control patients. Resemblance between donor and recipient microbiota profile post-FMT will be assessed with IS-PRO technique, this is defined as engraftment. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoint: changes in microbiota post-FMT. The will be assessed with the IS-PRO technique. Secondary endpoint: changes in scores on IBS questionnaire post FMT compared to baseline questionnaire score | — |
Countries
Netherlands
Outcome results
None listed