Hereditary spastic paraplegia (HSP) and Strumpell disease
Conditions
Interventions
The intervention group will receive a 5-week C-mill, whereas the control group
will first enter a 5-week waiting period of usual care, after which they
receive the same 5-week C-mill training. Befor
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Diagnosis of pure HSP based on molecular diagnosis (e.g. SPG-4 mutations) or based on inheritance. - Age between 18 and 70 years old. - Being able to independently walk barefoot on a level ground for 50 meters without a walking aid (use of orthopaedic devices or made-to-measure footwear is allowed).
Exclusion criteria
Exclusion criteria: -Other neurological or serious orthopaedic or psychiatric co-morbidity as well as previous surgical interventions of the lower extremities.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gait adaptability, as measured with the obstacle subtask of the Emory Functional Ambulation Profile (EFAP). | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary study parameters are the number of falls and the scores on the 10 meter walk test, 6min walk test and ladder gait test. In addition we will investigate whether individual improvement in gait adaptability as measured with the Mini-BEST test is statistically related to individual balance capacity, more than to lower extremity muscle strength or muscle tone. Furthermore, we will measure physical activity in daily life by wearable sensors. | — |
Countries
Netherlands
Outcome results
None listed