To examine the effect of dietary supplementation with fish oils and complex lipids on mitochondrial, physical, and cognitive function, in elderly humans.

To examine the effect of dietary supplementation with fish oils and complex lipids on mitochondrial, physical, and cognitive function, in elderly humans. - Membrane Lipid Study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON48470

Enrollment

108

Registered

2019-06-19

Start date

2019-12-16

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

veroudering, energiemetabolisme Ageing Metabolism

Interventions

FO (3g Total, 2.1g EPA & DHA) combined with 13g of either a CSP or with a skimmed milk (75%) and palm oil powder (25%) (SMPO) mixture.

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Males and females; - Caucasian; - Age * 65 years; - BMI * 20 kg/m2 * 30 kg/m2; - Normal physical activity levels: maximum of 1 hour per week engagement in moderate or high intensity structured exercise - Subject should be in sufficient health to participate in the experiments, to be judged by the site-specific responsible physician, based on the subject's medical history.

Exclusion criteria

Exclusion criteria: - Not meeting all inclusion criteria; - Habitual smoker within the past 5 years; - Excessive alcohol use (greater than 20g per day) and/or drug abuse; - Subjects with diagnosed diabetes mellitus type 2; - Significant food allergies or intolerances concerning the study products, e.g. cow*s milk protein allergy - Participation in another biomedical study within 1 month before the first study visit, possibly interfering with the study results; - Medication use known to hamper subject*s safety during the study procedures; - Subjects habitually taking fish oil supplements within 3-months of the initial study visit or habitually taking lipid supplements that are likely to affect the main study outcomes; - Subjects who do not want to be informed about unexpected medical findings; - Subjects who do not want their treating physician to be informed about unexpected medical findings; - Inability to participate and/or complete the required measurements.

Design outcomes

Primary

Measure	Time frame
The main outcome parameters relate to the anticipated differences in mitochondrial function and include ex vivo mitochondrial respiratory capacity as the main study endpoint.	—

Secondary

Measure	Time frame
Resting energy metabolism, body composition, and physical and cognitive function. Furthermore, markers of mitochondrial metabolism and mitochondrial respiratory capacity in skeletal muscle tissue will be determined.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)