blood glucose glucose tolerance
Conditions
Interventions
4-week intervention with 2.4g/d dried bitter-gourd supplements and a reference
intervention with 2.4g/d dried cucumber supplements.
Sponsors
Wageningen Universiteit
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: age 50-75yrs BMI >25 kg/m2 Having veins suitable for blood sampling via a catheter (judged by study nurse/medical doctor) Having one or more of the following criteria: o HbA1c >5.7% o fasting glucose >5.6mmol/L o two-hour glucose levels >7.8 mmol/L on the 75-g oral glucose tolerance test .
Exclusion criteria
Exclusion criteria: * History of gastro-intestinal surgery or having (serious) gastro-intestinal complaints * History of liver dysfunction (cirrhosis, hepatitis) or liver surgery * Kidney dysfunction (self-reported) * Use of medication/supplements that may influence the study results, such as medicines known to interfere with glucose homeostasis (judged by medical doctor) * Anaemia (Hb values 5 kg in the month prior to pre-study screening * Not willing to give up blood donation during the study * Current smokers * Alcohol intake *4 glasses of alcoholic beverages per day * Abuse of illicit drugs * Food allergies for products that we use in the study * Participation in another clinical trial at the same time * Being an employee of the Food, Health & Consumer Research group of Wageningen Food & Biobased Research or dept. human nutrition and health of Wageningen University.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| fasting levels of plasma glucose and 2hour plasma glucose after a 75-gram OGTT. | — |
Secondary
| Measure | Time frame |
|---|---|
| HbA1c, fructosamine, insulin (fasting and in response to a 75-OGTT). From the fasting glucose and insulin values we will calculate HOMA-IR score. We will also measure glucose responses during a three day controlled dietary period. | — |
Countries
Netherlands
Outcome results
None listed