depression psychosis
Conditions
Interventions
None listed
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: All groups: - male/female - age 20-55 - be able to read, write, and speak the language in which psychometric tests are provided Schizophrenia group - Primary diagnosis of schizophrenia (according to DSM-V) Depression group - Primary diagnosis of major depressive disorder (according to DSM-V)
Exclusion criteria
Exclusion criteria: All groups: - history of substance abuse (DSM-V) - history of neurological disorder (Parkinson's, epilepsy, Alzheimer's) - diagnosis of mental retardationTwo patient groups: - Bipolar disorder (DSM-V) - Obsessive-Compulsive disorder (DSM-V) - Eating disorder (DSM-V) - Attention-deficit hyperactivity disorder (DSM-V) - Received treatment with clozapine in the last 6 months before screening. - Experienced an acute exacerbation requiring hospitalization within the last 3 months. - major changes to medication (~30% dose change) in the 4 weeks prior to participation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We will use one main outcome measure per task as a formal primary endpoint. As a primary study endpoint for the Grip Strength task we will compare the percentage of hard task choices at different reward levels in the Grip Strength Task, which will be compared at a group level between MDD vs. matched healthy controls, SZ vs. matched healthy controls, and MDD vs SZ. For the Reinforcement Learning/Working Memory task, we will compare the number of optimal choices per set size condition (2-5) between these groups, and for the Doors task, percentage of trials on which a participant choose the other door after experiencing a loss (*lose-shifting*). The test-retest reliability of these outcome measures will be investigated. | — |
Secondary
| Measure | Time frame |
|---|---|
| - We will compare group-level (control, MDD, SZ) means and distributions (standard deviations) of our primary endpoints with previously published work. - Per task, we will compare event-related potential (ERPs, obtained from the EEG data) between the three groups - Relationships between primary task endpoints, EEG endpoints and symptom severity (SHAPS sum scores) will be investigated using correlational analyses - the intraclass correlation coefficient for all outcome measures mentioned under point 1 and 2 will be investigated. | — |
Countries
Netherlands
Outcome results
None listed