Epilepsy
Conditions
Interventions
None listed
Sponsors
Stichting Epilepsie Instellingen Nederland
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - A form of genetic generalised epilepsy (2 subjects), who do not use any anti-epileptic drugs (AED) - Aged over 18 years, AND, - Temporal lobe epilepsy (2 subjects), considered for epileptic surgery, whose AEDs will be tapered as part of usual diagnostic procedure - Admitted to the Epilepsy Monitoring Unit (EMU) - Aged over 18 years
Exclusion criteria
Exclusion criteria: - Pregnancy - Mentally incapacitated - Evidence of major radiological evidence of asymmetry between hemispheres - Any major neurological condition other than epilepsy - Any major psychiatric condition - Individuals with a cochlear implant or a deep brain stimulator - Metal and/or metal fragments in the head
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The network connectivity of the brain will be analysed using the VBMEG method. This method works by estimating the EEG activity of the cortical sources and the dynamic causal interactions between these. We will explore this methode and possibly change to investigate whether we can identify dynamic changes in the network connectivity in both focal and generalised epilepsy patients. Futhermore we will study whether anti-epileptic medication causes identifiable changes in the network connectivity. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Dose of anti-epileptic drugs on the day of the first and second TMS-EEG measurement - Differences in VBMEG results between visual versus TMS stimulation - Intolerance for research methods (TMS,EEG,EMG,MRI) | — |
Countries
Netherlands
Outcome results
None listed