Gait impairment in Parkinson's disease
Conditions
Interventions
None listed
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Men and women of age > 18 years with idiopathic Parkinson*s disease; - Presence of disabling gait impairment, which they wish to be improved; - Written informed consent.
Exclusion criteria
Exclusion criteria: - Presence of major stroke in history or a psychiatric disease not related to PD; - Presence of severe co-morbidity limiting ambulation (eg. orthopaedic problems); - Inability to walk unaided (with the exception of a customary cane); - Inability to walk for >3 minutes consecutively; - Severe visual impairments, hampering perception of visual cues; - Severe auditory impairments, hampering perception of auditory cues; - Severe cognitive impairments, hampering the ability to give personal informed consent or to comply to the study protocol. Additional exclusion criteria for Study II: - Presence of deep brain stimulation; - Presence of epilepsy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main parameter of Study I is the correlation of patient characteristics to the effectiveness of each compensation strategy. The effectiveness of compensation strategies is expressed as percent change in gait variability while applying the strategy, compared to baseline gait variability. The main parameter of Study II is the difference in cortical activity, as measured by ambulatory EEG, during the application of selected compensation strategies compared to during baseline gait. | — |
Secondary
| Measure | Time frame |
|---|---|
| Study I - As a secondary outcome parameter we will look at spatiotemporal gait parameters, as collected by the Vicon motion analysis system - We will also assess the percentage of time spent frozen (as in: freezing of gait) during the gait task. - Finally we will include a Likert scale to assess the patient's level of confidence concerning the newly-acquired compensation strategy, and his/her intention to use the strategy in daily life. Study II Spatiotemporal gait parameters, as collected by the Vicon motion analysis system | — |
Countries
Netherlands
Outcome results
None listed