Immunological response after early extra and regular MMR immunization; 6 years follow-up

Immunological response after early extra and regular MMR immunization; 6 years follow-up - Early extra MMR immunization; 6 years follow-up

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON48447

Enrollment

Registered

2019-05-29

Start date

2019-10-02

Completion date

Unknown

Last updated

2025-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Measles infection paramyxovirus

Interventions

None listed

Eligibility

Age

2 Years to 11 Years

Inclusion criteria

Inclusion criteria: •Previous participation in the study on the immunological effects of early measles vaccination, as described in a separate study protocol (NL45616.094.13/IIV-273) •The parents/legally representatives accept participation in the trial according to the described procedures •Presence of a signed informed consent •Children must have received their NIP vaccinations according to schedule.

Exclusion criteria

Exclusion criteria: •Receiving immunosuppressive medication •Presence of a serious disease that requires medical care that can interfere with the results of the study •Known or suspected immunological disorder •Bleeding disorders

Design outcomes

Primary

Measure	Time frame
• Measles specific serum neutralizing antibodies 6 years after MMR-1 at 14 months of age	—

Secondary

Measure	Time frame
• Measles specific serum IgG antibody and avidity (Luminex), and functional antibody characteristics prior 6 years after MMR-1 at 14 months of age • Serum IgG antibody concentrations against mumps and rubella (Luminex) 6 years after MMR-1 at 14 months of age • Antibodies against other NIP vaccines 6 years after MMR-1 at 14 months of age	—

Countries

Netherlands

Outcome results