Zooming in at microvascular function in the Rotterdam Study with 7T MRI

Zooming in at microvascular function in the Rotterdam Study with 7T MRI - Zoom@Rotterdam

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON48445

Enrollment

200

Registered

2019-09-26

Start date

2021-05-06

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

neurodegeneratieve aandoeningen Dementia vascular pathology

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Participant in Rotterdam Study who has undergone at least one previous assessment in the study centre (including brain MRI and cognitive testing) and who will visit the study centre from June 2019 onwards for re-examination - >60 years of age - Written informed consent

Exclusion criteria

Exclusion criteria: - Inclusion criteria are not met - Unwillingness or inability to give written informed consent - Clinical diagnosis of dementia or previous stroke. - Contraindications for 7T MRI (pacemaker, aneurysm clip, cochlear implant etc.) - Major neurological conditions affecting brain structure (e.g. multiple sclerosis, epilepsy, parkinson*s disease)

Design outcomes

Primary

Measure	Time frame
Measures of microvascular function as assessed on noninvasive 7T MRI: - Mean velocity and pulsatility index of perforator flow, both in the basal ganglia and in the semioval center; - Cerebrovascular reactivity (CVR) to a hypercapnic stimulus.	—

Secondary

Measure	Time frame
Not applicable.	—

Countries

Netherlands

Outcome results