Hersenactiviteit na acute stress. Stress-related brain acitivity
Conditions
Interventions
Participants are randomly assigned to either a stress condition or a control
condition of the Trier Social Stress Test for Children (TSST-C
Buske-Kirschbaum et al., 1997):
- healthy term-born children-non-stress (n=25)
- healthy term-born children-stress (n=25)
- preterm born children-non-stress (n=25)
- preterm born children-stress (n=85
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
2 Years to 11 Years
Inclusion criteria
Inclusion criteria: Extremely preterm born children - Gestational age 38 weeks - Age and gender at assessment are matched to an extremely preterm born child included in the study.
Exclusion criteria
Exclusion criteria: Extremely preterm born children - Major chromosomal and/or congenital anomalies. - Current psychiatric disorder (i.e., as indicated by a current DSM-V diagnosis) - Ferromagnetic objects inside the body (see MRI screening) - Claustrophobia - Use of medication known to influence HPA-axis functioning (i.e., corticosteroid medication) - Parents are not willing to provide informed consent - Parents are not allowing unexpected findings to be reported to themselves or their general practitioner(s)., Healthy controls In addition to the previously mentioned exclusion criteria for preterm born children, the following criteria will disqualify prospective control participants from participating: - Relative of the included preterm born child. *
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Brain activity measured with fMRI during emotion processing (i.e., IAPS), behavioural control (i.e., SSAT), and rest, following acute stress in premature born children compared to full-term born children. - Factors determining variability underlying brain activity following acute stress in extremely preterm born children, such as coping strategies, life events, and personality, amongst others. | — |
Secondary
| Measure | Time frame |
|---|---|
| To study basal and stress-induced changes in hormonal levels (i.e., cortisol, alpha-amalyse), heart-rate, and perceived stress (i.e., VAS) in preterm born children compared to healthy controls. | — |
Countries
Netherlands
Outcome results
None listed