the effect of hyperbaric oxygen therapy on immune response and oxidative stress

the effect of hyperbaric oxygen therapy on immune response and oxidative stress - HOIROS study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON48412

Enrollment

Registered

2019-09-23

Start date

2019-10-24

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Immuun response and reactive oxygen species inflammation & oxidative stress

Interventions

The volunteers will receive a total of three HBOT sessions. Hyperbaric treatment in the intervention group will consist of three treatments breathing 100% air at a pressure of 2.4 atmosphere absolut

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Male - Healthy - Age 18-40 - Be able to read and understand Dutch

Exclusion criteria

Exclusion criteria: - Language barrier - Unable to give informed consent - Unfit for hyperbaric oxygen therapy as assessed by the hyperbaric physician

Design outcomes

Primary

Measure	Time frame
Immunologic effects defined by neutrophil intracellular ROS generation, phagocytosis assays, plasma cytokine concentrations, HLA-DRA mRNA expression, malondialdehyde concentration and ex vivo whole blood stimulation.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)