non-melanoma skin cancer skin cancer
Conditions
Interventions
Broad-band UV exposure of the unprotected back skin of the volunteers at
UV-dose of 7.5, 15, 30 and 60 mJ/cm2. The sunscreen protected (SPF 50+) skin
will be exposed at a UVR-dose of 150 mJ/cm2. 5 t
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Male and female individuals between 18 and 65 years. Fitzpatrick skin types II or III. Free of any dermatological or systemic disorder which would interfere with the results, at the discretion of the investigator. Individual who has read, understood and signed an informed consent document relating to the specific study to which he/she is subscribing. Individuals with no known abnormal response to sunlight (e.g. polymorphic eruption) or (ingredients of) sunscreens. Willingness to actively participate in the study and come to the scheduled visits Willingness to discontinue the use of detergents (e.g. soaps) and cosmetics products (e.g. creams, moisturizers) in the treatment area throughout the course of the study Willingness to avoid any exposure of the test area to artificial or natural ultraviolet light throughout the course of the study
Exclusion criteria
Exclusion criteria: Taking medication which in the opinion of the investigator would mask or interfere with the results. With chronic skin allergies. With suntan of sunburn Breastfeeding Pregnancy or intention to become pregnant over the duration of the study Participation in, or being in the waiting period for another study Individual with moles, tattoos, scars, irritated skin, hairs, etc. at the test area that could influence the investigation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The levels of urocanic acid isomers, immunological factors (chemokines, cytokines, MMP (metalloproteinases)), and angiogenesis factors in the the stratum corneum. | — |
Secondary
| Measure | Time frame |
|---|---|
| n.a. | — |
Countries
Netherlands
Outcome results
None listed