Observing Electrical Brain Responses during Processing of Nociceptive Stimuli around the Detection Threshold combined with a Cold Pressor Test: an Explorative Study

Observing Electrical Brain Responses during Processing of Nociceptive Stimuli around the Detection Threshold combined with a Cold Pressor Test: an Explorative Study - CPT-study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON48333

Enrollment

Registered

2019-12-19

Start date

2020-01-22

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronische pijn, centrale sensitisatie, perifere sensitisatie pain

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Healthy subjects: Age of 18 or above; No history of pathological pain. FBSS patients: Age of 18 or above.

Exclusion criteria

Exclusion criteria: Patient*s refusal during the study; Skin problems at the site of the pain sensitivity measurement; Communication problems or incapable of following the instructions; Pregnancy; Consumption of alcohol or drugs within 24 hours before the experiment; Pain complaints at the time of the experiment; A medical history of chronic pain; Unable to undergo pain sensitivity measurement; Cardiac arrhythmias; Heart valve defects; Heart muscle diseases; Open wound on the foot to be immersed; Frequent caffeine use (>8 units/day); Smokers (>5 cigarettes/day); BMI > 30 kg * m-2; Type 1 or 2 diabetes mellitus.

Design outcomes

Primary

Measure	Time frame
The nociceptive detection threshold EEG signals	—

Secondary

Measure	Time frame
Current pain (NRS) Average pain in the lasts seven days (NRS) Questionnaire about symptoms of central sensitization: central sensitization inventory (CSI) Current medication intake Patient characteristics: age, sex, BMI Immersion time and water temperature Neurological evaluation FBSS duration (in months, patients only) pQST/PPDT	—

Countries

Netherlands

Outcome results