coronary artery disease
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Age >18 years. * Presence of an epicardial stenosis of *50% diameter stenosis in the left anterior descending (LAD) artery. * Presence of stable angina (Canadian Cardiovascular Society (CCS) score I-III). Able to understand and sign the informed consent.
Exclusion criteria
Exclusion criteria: Patients 13mm septal wall thickness). * Unable to undergo percutaneous intervention or receive adenosine (severe reactive airway disease, severe hypotension or high-grade Atrio-Ventricular (AV) block in the absence of a pacemaker. * Signs or history of cardiomyopathy. * Signs of (peri)myocarditis * Collateral formation in target vessel. * CABG to target vessel. * Renal failure (MDRD calculated eGFR of
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Correlation of cDSA-derived parameters and Doppler flow velocity-derived parameters of microvascular resistance during hyperemic flow and coronary flow reserve, pre-and post PCI. Patiënts will receive a PCI of the LAD following standard of care. However, before the PCI 2 additional angiograms will be acquired, before and after administration of adenosine. Simultaneously, intracoronary flow and pressure will be measured with a Combowire positioned in the LAD. Following the PCI the same will be repeated. | — |
Secondary
| Measure | Time frame |
|---|---|
| Not applicable. | — |
Countries
Netherlands
Outcome results
None listed