Metabolisme lipoprotein metabolism risk factors for cardiovascular disease
Conditions
Interventions
Following a 2-week run-in period, volunteers will be randomly allocated to test
diets providing 15% energy of the hardstock from test fats (palm stearin kernel
blended with rapeseed oil (PSKb) or a
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Apparently healthy men and women - Non-smoking - Age: 35-65 yrs - Having a general practitioner - Signed informed consent - Agreeing to be informed about medically relevant personal test-results by a physician - For the subgroup (Maastricht only): No contra-indication for MRI measurements
Exclusion criteria
Exclusion criteria: - Having a medical condition which might impact study measurements - Use of over-the-counter and prescribed medication, which may interfere with study measurements - Use of food supplements or plant-sterol/stanol-enriched foods or supplements in the three months prior to the screening and/or during the study; - Reported alcohol consumption * 21 units/week; - Reported weight loss or gain of 3 kg or more during a period of 2 months prior to screening - Reported dietary habits: medically prescribed diet, allergy/intolerance to test products that will be provided during the study - Blood donation in the past 3 months - Drug abuse - Reported participation in another nutritional or biomedical trial 3 months prior to screening - Serum lipids: treatment recommended according to the *Multidisciplinaire richtlijn Cardiovasculair risicomanagement* - Body mass index 35 kg/m2
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study endpoint is the difference in the total to HDL-cholesterol ratio as measured at the end of the intervention periods. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints include the postprandial lipidemic and glycaemic effects after chronic exposure to these fats. | — |
Countries
Netherlands
Outcome results
None listed