abdominal aortic aneurysm enlargement of the abdominal aorta
Conditions
Interventions
None listed
Sponsors
Rijnstate Ziekenhuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Young healthy group: Male or female between the age of 18 and 40 years old; - Older healthy group: Male or female, which are age-/sex-matched with the AAA patients group; - AAA patients group: Male or female with an abdominal aortic aneurysm who is still under surveillance, with a diameter between 3.0 and 5.0 cm and at least 18 years old. These patients may participate in the 1-2-3 Trial, which is a similar approved investigation by CMO region Arnhem-Nijmegen with registration number 2019-5216. - Informed consent form understood and signed;
Exclusion criteria
Exclusion criteria: - Psychiatric or other conditions that may interfere with the study; - Participating in another clinical study, interfering on outcomes; - With regard to the necessary quality of the ultrasound images, BMI * 30 kg/m2; - Increased risk for coronary spasms (score Rose-questionnaire * 2); - Presence of Raynaud*s phenomenon, Marfan syndrome, chronic pain syndrome at upper extremity(s), presence of an AV fistula or shunt, open wounds to the upper extremity(s), and/or scleroderma associated with placing the hand in ice water; - Recent (140 mmHg and/or diastolic blood pressure >90 mmHg o Cardiovascular history o Antihypertensive medication
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study endpoint is the results of the CPT of the abdominal aorta and the carotid artery for each participant; this can be either a vasodilation or vasoconstriction in response to the sympathetic stimulus. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary parameters include: - Other CPT results of the abdominal aorta and the carotid artery o Magnitude and timing of the blood flow and perfusion response o Blood pressure and heart rate response - Age | — |
Countries
Netherlands
Outcome results
None listed