RA Rheumatoid artritis
Conditions
Interventions
None listed
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Age 18 years or older - Ability to understand the patient information form and ability to provide written informed consent - Written informed consent For patients: - a definite diagnosis of rheumatoid arthritis based on the ACR/EULAR 2010 criteria for RA For healthy controls: - No previous prolonged and/or current symptoms of inflammatory arthritis
Exclusion criteria
Exclusion criteria: - Individuals who fail to meet the inclusion criteria - Individuals for whom relevant safety issues apply (for example, dyspnoea or severe anaemia) that preclude the provision of sputum, saliva, peripheral blood or feces - Individuals who are currently suffering from upper airway infections, influenza or other contagious (lung)diseases - Dental treatment within the previous month - The presence of oral ulcers - Individuals with known inflammatory bowel disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The detection of several RA associated antibodies and their distinct antibody features in feces, saliva and sputum of patients. This will be compared to the autoantibody profile in serum. Among the distinct antibody features that will be explored are isotype usage, fine-specificity, glycosylation of Fc- and Fab-region, avidity and affinity. | — |
Secondary
| Measure | Time frame |
|---|---|
| The presence and characteristics of other biomarkers reflecting the mucosal immune response in feces, saliva and sputum of patients with RA and healthy controls. These biomarkers include: the presence of (anti-)inflammatory cytokines and chemokines and the structure and origin of antigens. Furthermore, collaboration with other centers may allow the investigation of the microbiome composition in the future. | — |
Countries
Netherlands
Outcome results
None listed