Onderzoek heeft geen betrekking op een aandoening, maar bestudeert de effecten van hormonen op het vaderschap n.a.
Conditions
Interventions
administration of (1) oxytocin, (2) vasopressin, or (3) placebo
Sponsors
Vrije Universiteit
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Fathers who have had their first baby, child*s age
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: Endocrine disorders Smoking Alcohol and drug abuse Use of medication potentially interfering with the endocrine system MRI contraindications, including metallic foreign objects, neurological disorder and claustrophobia Cardiovascular disease Nose injuries and disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The first main study parameter is activity in documented parenting-related brain areas. We will examine the effects of oxytocin and vasopressin on activity in these areas in fathers during processing of infant signals and threat to infant in tasks designed to elicit protective responses. The second main study parameter is parenting behavior, including handgrip strength during infant cry sounds, sensitivity, involvement, and protection. We will examine the effects of oxytocin and vasopressin on these parenting dimensions. | — |
Secondary
| Measure | Time frame |
|---|---|
| We will examine the link between neural and behavioral effects of oxytocin and vasopressin administration, and explore the extent to which effects of oxytocin and vasopressin are moderated by father*s early childhood experiences. We will measure hormonal levels to explore the associations with involvement in infant care (cortisol, testosterone, oxytocin), to control for cross-reactions (oxytocin-vasopressin), and to examine mechanisms (testosterone * estradiol * oxytocin and testosterone - vasopressin). | — |
Countries
Netherlands
Outcome results
None listed