Voedingsonderzoek plasmakinetics of GABA
Conditions
Interventions
On a test day the research subjects will consume either tomatoes with 1 gram of
GABA, a dose of 1 gram GABA supplement dissolved in a maximum of 1 litre water,
a glutamate supplement with a maximum
Sponsors
Wageningen Universiteit
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - BMI between 18.5 and 25 kg/m2 - Age is between 18 and 28 years - Good general health - Male - Veins suitable for blood sampling - Able to speak Dutch
Exclusion criteria
Exclusion criteria: - Is currently suffering from a disease including mental disorders - Has had any gastrointestinal condition/disease within the 3 months prior to the intervention - Haemoglobin (Hb) level 2 kg in the month prior to the intervention - Use of dietary supplements, 3 weeks before-, or during the intervention. - Allergic to products that are provided as part of the standardised diet - Following a specific diet (e.g. vegetarian, gluten free) - Allergic to tomatoes - (History of) drug abuse, in this case meaning >1 x per month use of recreational drugs - Smoking - Alcohol consumption of >10 standardised glasses per week. - Recent or planned blood donation (
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study outcome is the plasma-time curve of GABA. This will be evaluated using descriptive kinetics: maximum peak height (Cmax), time-to-peak (Tmax), and area-under-the-curve (AUC). | — |
Secondary
| Measure | Time frame |
|---|---|
| - To evaluate the effects of an oral GABA dose and tomatoes on the plasma concentrations of glutamate in healthy men. - To evaluate the effects of a single oral glutamate dose on the plasma concentrations of GABA and compare this to the plasma concentrations of GABA after the intake of a tomatoes. | — |
Countries
Netherlands
Outcome results
None listed