Cognitive and attention disorders and disturbances executive function reading
Conditions
Interventions
Not applicable.
Sponsors
Radboud Universiteit Nijmegen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Healthy volunteers between 18 and 45 years old; Native Dutch speakers. Right-handed
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: • (History of) psychiatric treatment; • (History of) psychosis or mania; • (History of) neurological diseases (e.g. Parkinson, epilepsie); • (History of) neurological treatment; • (History of) endocrine treatment; • (History of) cardiac or vascular diseases; • (History of) blood illness (e.g. anemia, porphyria); • (History of) endocrine / metabolic disease; • (History of) of stomach or gastrointestinal tract disease; • (History of) vasovagale reflex syncope; • Experience of irregular sleep-wake rhythm; • (History of) obstructive respiratory disease • (History of) frequent autonomic failure (e.g. vasovagal reflex syncope); • (History of) clinically significant renal or hepatic disease; • (History of) epilepsy in adulthood (i.e. no insult after 18 years of age, no current medication for epilepsy, and no insult in the last five years); • (History of) glaucoma; • (History of) drug addication (e.g. opiate, (meth)amphetamine, lysergic acid diethylamide, cocaine, solvents or barbiturate) or alcohol dependence; • One first degree or two or more second degree family members with a history of sudden death or ventricular arrhythmia; • Problems slicking or problems with the esophagus (); • Frequent experience of headrush (vertigo); • Past or current treatment of hyperthyroidism; • Current experience of an acute infection (e.g. fever); • First degree family member with schizophrenia or bipolar disorder; • Abnormal hearing or (uncorrected) vision; • Use of psychotropic medication or recreational drugs weekly or more over a period of more than three months in the last 6 months; • Use of drug within 2 weeks prior to the start of the study; • Use of alcohol within the last 24 hours before each test session; • Dependence on cannabis or weekly cannabis usage for the last 6 months; • Strong smoking behaviour starting at more than 1 package of cigarettes per week; • Hypersensitivity for e.g. beta blockers or methylphenidate; • Previous use of Methylphenidate (Ritalin); • Uncontrolled hypertension, defined as diastolic blood pressure at rest >95 mmHg or systolic blood pressure at rest >180 mmHg; • Irregular sleep/wake rhythm (e.g. regular nightshifts or cross timeline travel); • Possible pregnancy or breastfeeding; • Lactose intolerance (because the placebo pill will be a lactose product); • Language related disabilities (e.g. dyslexia, stuttering); • Daily intense physical training.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary study parameters include participants' task behavioral performance (e.g. accuracy, reaction times) and electroencephalographic (EEG) measures. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters include participants' baseline characteristics (e.g. working memory capacity, linguistic experience), and general processing speed. | — |
Countries
Netherlands
Outcome results
None listed