Ischaemia reperfusion injury vascular damage
Conditions
Interventions
Three sessions of 30-min exercise (high intensity cycling, moderate intensity
cycling, handgrip exercise), single session of ischaemic preconditioning, and a
control session.
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Adults >18 years,
Exclusion criteria
Exclusion criteria: - Presence of an absolute contra-indication for the performance of exercise (see also SOP Inspanningstest Department of Physiology): - Acute myocardial infarction (3-5 days) - Unstable angina - Uncontrolled arrhythmias causing symptoms or hemodynamic compromise - Active endocarditis - Acute myocarditis or pericarditis - Symptomatic severe aortic stenosis - Uncontrolled heart failure - Acute pulmonary embolus or pulmonary infarction - Thrombosis of lower extremities - Suspected dissecting aneurysm - Uncontrolled asthma - Pulmonary edema - Respiratory failure - Acute noncardiopulmonary disorder that may affect exercise performance or be aggravated by exercise (i.e. infection, renal failure, thyrotoxicosis) - Mental impairment leading to inability to cooperate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in endothelial function (measured with flow mediated dilation) before and after ischaemia reperfusion injury(induced by 15-minute ischaemia to the forearm, followed by 20-minutes of reperfusion). | — |
Secondary
| Measure | Time frame |
|---|---|
| Plasma nitrite/nitrate levels, (anti)inflammatory markers, metabolomics as will be performed in plasma. | — |
Countries
Netherlands
Outcome results
None listed